![]() ![]() 2003 25(2):111–117.Volume 19, Issue 3 (July & August 2014 2014)Ĭomparison of sexual self-efficacy and sexual function in fertile and infertile women referred to health centers in Mashhad in 1392 Significance of HTLV-1 proviral load quantification by real-time PCR as a surrogate marker for HTLV-1-infected cell count. Kamihira S, Dateki N, Sugahara K, Hayashi T, Harasawa H, Minami S, Hirakata Y, Yamada Y. Triple therapy with prednisolone, Pegylated interferon and sodium valproate improves clinical outcome and reduces human T-cell leukemia virus type 1 (HTLV-1) Proviral load, tax and HBZ mRNA expression in patients with HTLV-1-associated myelopathy/tropical spastic Paraparesis. doi: 10.1016/j.jcv.2011.07.004.īoostani R, Vakili R, Hosseiny SS, Shoeibi A, Fazeli B, Etemadi MM, Sabet F, Valizade N, Rezaee SA. High prevalence of HTLV-I infection in Mashhad, Northeast Iran: a population-based seroepidemiology survey. Rafatpanah H, Hedayati-Moghaddam MR, Fathimoghadam F, Bidkhori HR, Shamsian SK, Ahmadi S, Sohgandi L, Azarpazhooh MR, Rezaee SA, Farid R, et al. Epidemiological aspects and world distribution of HTLV-1 infection. Modes of human T cell leukemia virus type 1 transmission, replication and persistence. However, high level of RORγt may inhibit Th1 response and complicated in ATLL progressions.ĪKT1 BAD FOXP3 HBZ HTLV-1-proviral load IFNλ3 RORγt.Ĭarpentier A, Barez PY, Hamaidia M, Gazon H, de Brogniez A, Perike S, Gillet N, Willems L. The present and our previous study demonstrated that HTLV-1-PVL and HBZ and host AKT1 and Rad 51 are novel candidates for molecular targeting therapy of ATLL. Finally, the IFNλ3 expression between ATLLs (31.92 ± 26.02) and ACs (1.46 ± 0.63) (P = 0.01) and ACs and HAM/TSPs (680.62 ± 674.6) (P = 0.02) were statistically different, but not between ATLLs and HAM/TSPs. However, BAD expression in ATLL was slightly higher than ACs and HAM/TSPs and not significant. The DNA and mRNA from peripheral blood mononuclear cells were extracted for gene expression assessments via qRT-PCR, TaqMan assay, and then confirmed by western blotting.Īs it was expected, the HTLV-1-PVL were higher in ATLLs than ACs (P = 0.002) and HAM/TSP (P = 0.041). The study was conducted in ATLLs, HTLV-1-associated myelopathy/tropical spastic paraparesis patients (HAM/TSPs) and HTLV-1-asympthomatic carriers (ACs). In this study, the HTLV-1 proviral load (PVL) and HBZ as viral elements and AKT1, BAD, FOXP3, RORγt and IFNλ3 as the host factors were investigated. Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of HTLV-1-host interactions in infected TCD4+ cells. ![]()
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